Devlopment and Evaluation of Ketoprofen Loaded lipid Microspheres for controlled release

The present study envisages formulation of wax microparticulate drug delivery system. The objective of the present study was to minimise the unwanted side effects of Ketoprofene drug formulated by Congealable disperse encapsulation method using biodegradable waxes such as beeswax, ceresin wax microspheres using a wetting agent. Solid, discrete, reproducible free flowing microspheres were obtained. The yield of the microspheres was up to 92.0%. Microspheres prepared have smooth surfaces. These microspheres have free flowing and good packing properties and shows the characterization values well within the limit that are angle of repose, % Carr’s index and tapped density. More than 92.0% of the isolated spherical microspheres were in the particle size range of 29.50 μm as confirmed by scanning electron microscopy (SEM) photographs. The drug loaded in microspheres was found to be stable and compatible with waxes as confirmed by FTIR studies. The drug release from invitro study followed matrix model and it shows initial burst release followed by constant release up to 24hrs